Alveolar type II cell Na,K-ATPase is upregulated during mechanical ventilation-induced pulmonary edema.
نویسندگان
چکیده
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منابع مشابه
Gas Exchange Disturbances Regulate Alveolar Fluid Clearance during Acute Lung Injury
Disruption of the alveolar-capillary barrier and accumulation of pulmonary edema, if not resolved, result in poor alveolar gas exchange leading to hypoxia and hypercapnia, which are hallmarks of acute lung injury and the acute respiratory distress syndrome (ARDS). Alveolar fluid clearance (AFC) is a major function of the alveolar epithelium and is mediated by the concerted action of apically-lo...
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While a number of whole cell mechanical models have been proposed, few, if any, have focused on the relationship among plasma membrane tension, plasma membrane unfolding, and plasma membrane expansion and relaxation via lipid insertion. The goal of this communication is to develop such a model to better understand how plasma membrane tension, which we propose stimulates Na(+)-K(+)-ATPase activi...
متن کاملInvited review: lung edema clearance: role of Na(+)-K(+)-ATPase.
Acute hypoxemic respiratory failure is a consequence of edema accumulation due to elevation of pulmonary capillary pressures and/or increases in permeability of the alveolocapillary barrier. It has been recognized that lung edema clearance is distinct from edema accumulation and is largely effected by active Na(+) transport out of the alveoli rather than reversal of the Starling forces, which c...
متن کاملVentilator-associated lung injury decreases lung ability to clear edema in rats.
Ventilator-associated lung injury (VALI) is caused by high tidal volume (VT) excursions producing microvascular leakage and pulmonary edema. However, the effects of VALI on lung edema clearance and alveolar epithelial cells' Na,K-ATPase function have not been elucidated. We studied lung edema clearance in the isolated-perfused rat lung model after ventilation for 25, 40, and 60 min with high VT...
متن کاملLung Edema Clearance: 20 Years of Progress Invited Review: Lung edema clearance: role of Na -K -ATPase
Sznajder, J. I., P. Factor, and D. H. Ingbar. Invited Review: Lung edema clearance: role of Na -K -ATPase. J Appl Physiol 93: 1860–1866, 2002. 10.1152/japplphysiol.00022.2002.—Acute hypoxemic respiratory failure is a consequence of edema accumulation due to elevation of pulmonary capillary pressures and/or increases in permeability of the alveolocapillary barrier. It has been recognized that lu...
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عنوان ژورنال:
- Chest
دوره 105 3 Suppl شماره
صفحات -
تاریخ انتشار 1994